| 摘要 |
PROBLEM TO BE SOLVED: To provide an oral immediate release formulation in solid form and for a low molecular weight thrombin inhibitor having pH dependant dissolution. SOLUTION: The oral immediate release formulation in solid form comprises (a) a low molecular weight peptide thrombin inhibitor having pH dependent solubility and <300μm particle size, and (b) a combination of microcrystalline cellulose with a filler selected from a group consisting of ultramicro cellulose, crosslinked carboxymethyl cellulose, crosslinked hydroxypropyl cellulose, gelatinized starch, potato starch, rice starch, wheat starch, crosslinked polyvinylpyrrolidone, cation exchange resin and their mixtures and of an amount higher than 35% W/W of the formulation. COPYRIGHT: (C)2007,JPO&INPIT
|
