ORAL PHARMACEUTICAL COMPOSITION

摘要

An oral pharmaceutical composition comprising about 0.1 to about 25% by weight of selective hydrophobic drug , about 0.5 to about 90% by weight of a lipophilic naturally occurring wetting agent, solubilizer and stabilizer comprising rice oil, about 0.5 to about 90% by weight of a lipophilic component, about 0.5 to about 90% by weight of a hydrophilic co-surfactant and about 0.5 to about 90% by weight of a surfactant, wherein the relative proportion of selective hydrophobic drug, hydrophilic components, lipophilic components and surfactants in said composition is such that upon dilution with water to a ratio of 1 part by weight of said composition to 100 parts by weight of water, an oil-in-water microemulsion having average particle size below 100 nm is spontaneously formed.