NOVEL CERCOSPORAMIDE DERIVATIVE

摘要

The invention relates to a novel cercosporamide derivative which has a good hypoglycemic effect and is useful for a therapeutic drug and/or preventive drug for diabetes, a pharmacologically acceptable salt thereof or an ester thereof. [MEANS FOR SOLVING PROBLEMS] The cercosporamide derivative having the general formula (I): (wherein X represents an oxygen atom or the like, R<SUP>1</SUP> represents a hydrogen atom or a C<SUB>1</SUB>-C<SUB>6</SUB> alkyl group, R<SUP>2</SUP> represents a hydrogen atom, a C<SUB>1</SUB>-C<SUB>6</SUB> alkyl group or a C<SUB>1</SUB>-C<SUB>6</SUB> halogenated alkyl group, R<SUP>3</SUP> represents a hydrogen atom or a C<SUB>1</SUB>-C<SUB>6</SUB> alkyl group, R<SUP>4</SUP> represents a C<SUB>6</SUB>-C<SUB>10</SUB> aryl group which may be substituted with 1 to 5 groups independently selected from the substituent group (a) or the like, n represents 1, 2 or 3, and the substituent group (a) represents a halogen atom, a C<SUB>1</SUB>-C<SUB>6</SUB> alkyl group, a C<SUB>1</SUB>-C<SUB>6</SUB> halogenated alkyl group, a C<SUB>2</SUB>-C<SUB>6</SUB> alkenyl group, a C<SUB>2</SUB>-C<SUB>6</SUB> alkynyl group, a C<SUB>1</SUB>-C<SUB>6</SUB> alkoxy group, a C<SUB>1</SUB>-C<SUB>6</SUB> halogenated alkoxy group, a C<SUB>2</SUB>-C<SUB>6</SUB> alkenyloxy group, a C<SUB>2</SUB>-C<SUB>6</SUB> alkynyloxy group and the like), a pharmacologically acceptable salt thereof or an ester thereof.