NOVEL SUBSTITUTED 1,2,3-T?AZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOT?ENE BIOSYNTHESIS INHIBITORS

摘要

The instant invention provides compounds of Formula I which are leukotpene biosynthesis inhibitors. Z is a fused (optionally sulfo-oxidized) thiophen ring or a fused pyrrol ring R2-R4 are selected from a variety of substituents Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti¬ inflammatory and cytoprotective agents.