发明名称 Migrastatin analogs and uses thereof
摘要 In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R<SUB>1</SUB>-R<SUB>6</SUB>, R<SUB>a-R</SUB><SUB>C</SUB>, Q, Y<SUB>1</SUB>, Y<SUB>2 </SUB>and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
申请公布号 US2007037783(A1) 申请公布日期 2007.02.15
申请号 US20040551152 申请日期 2004.03.26
申请人 HUANG XIN-YUN;DANISHEFSKY SAMUEL J;GAUL CHRISTOPH;NJARDARSON JON T 发明人 HUANG XIN-YUN;DANISHEFSKY SAMUEL J.;GAUL CHRISTOPH;NJARDARSON JON T.
分类号 A61K31/541;A61K31/395;A61K31/4025;A61K31/422;A61K31/427;A61K31/452;A61K31/496;A61K31/5377 主分类号 A61K31/541
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