发明名称 |
Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis |
摘要 |
The present invention is directed to derivatives of gambogic acid and analogs thereof. Exemplary gambogic acid derivatives of the present invention include, among others, derivatives substituted in the C10 and C28 positions of gambogic acid. The present invention also relates to the discovery that certain preferred compounds of the present invention are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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申请公布号 |
US7176234(B2) |
申请公布日期 |
2007.02.13 |
申请号 |
US20030609670 |
申请日期 |
2003.07.01 |
申请人 |
CYTOVIA, INC. |
发明人 |
CAI SUI XIONG;KASIBHATLA SHAILAJA;OLLIS KRISTIN P.;ZHANG HAN-ZHONG;DREWE JOHN A.;TSENG BEN;SIRISOMA NILANTHA SUDATH |
分类号 |
A61K31/352;C07D313/06;C07D493/20;C12N5/02 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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