Pentanoic acid derivatives

摘要

The compound of the formula (I): wherein R¹ is alkyl substituted by fluorine(s); R² is hydroxy, alkoxy, alkoxy substituted by phenyl, NR³R⁴, in which R³, R⁴ is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R³ and R⁴, taken together a saturated heterocyclic ring or amino acid residues; and non-toxic salts thereof and acid addition salts thereof. The compounds of the present invention of the formula (I) and the compounds of the formula (X): wherein n is 0 or 1, R¹¹ is hydrogen and chlorine, R⁵ is R⁷-CH₂- or R⁸, or R⁵ and R¹¹, taken together is alkylidene; R⁶ is hydroxy, alkoxy, alkoxy substituted by phenyl, NR⁹R¹⁰, in which R⁹, R¹⁰ is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl-substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R⁹ and R¹⁰, taken together a saturated heterocyclic ring or amino acid residues, R⁷ is (i) F-(CH₂)_m- or F₃C-CH₂-, (ii) alkyl substituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; R⁸ is alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy; non-toxic salts and acid addition salts thereof are useful for prevention and/or treatment for neurodegenerarive disease (Alzheimer's disease etc.) and neuronal dysfunction by stroke or traumic injury (Multiple sclerosis etc.) etc.