| 发明名称 |
Tools for the diagnosis and treatment of Alzheimer's disease |
| 摘要 |
The present invention relates to phosphorylated tau protein epitopes associated with Alzheimer's disease, to protein kinases responsible for tau protein epitope phosphorylation, and to antibodies specific for the tau epitopes. Additionally, the present invention relates to pharmaceutical compositions, methods for detection, and methods of testing drugs effective in dissolving paired helical filaments associated with Alzheimer's disease. |
| 申请公布号 |
US7176290(B2) |
申请公布日期 |
2007.02.13 |
| 申请号 |
US20020066810 |
申请日期 |
2002.02.04 |
| 申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNGDER WISSENSHAFTEN, E.V. |
发明人 |
MANDELKOW EVA-MARIE;MANDELKOW ECKHARD;LICHTENBERG-KRAAG BIRGIT;BIERNAT JACEK;DREWES GERARD;STEINER BARBARA |
| 分类号 |
C07K16/00;A61K38/00;A61K39/00;C07K14/47;C07K16/18;C07K16/40;C12N5/00;C12N5/06;C12N5/16;C12N9/12;C12N9/16;C12P21/08;G01N33/68 |
主分类号 |
C07K16/00 |
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