发明名称 |
Methods of optimizing antibody variable region binding affinity |
摘要 |
The present invention relates to compositions and methods of producing higher affinity molecules, and in particular, higher affinity antibodies. Specifically, the invention contemplates methods of mutagenesis to create a population of oligonucleotides coding for altered polypeptides that are expressed in a host cell and subsequently sequenced to determine the amino acid determinants conferring higher affinity.
|
申请公布号 |
US7175996(B1) |
申请公布日期 |
2007.02.13 |
申请号 |
US20020110141 |
申请日期 |
2002.10.29 |
申请人 |
APPLIED MOLECULAR EVOLUTION |
发明人 |
WATKINS JEFFRY D.;HUSE WILLIAM D.;WU HERREN |
分类号 |
C12P21/06;A61K39/395;C07H21/04;C07K16/28;C07K16/36;C07K16/46;C12P21/08 |
主分类号 |
C12P21/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|