发明名称 |
Process for the production of mycophenolate mofetil |
摘要 |
The present invention relates to a new and economically attractive process for the production of mycophenolate mofetil in a high degree of pharmaceutically acceptable purity, which comprises the reaction of a reactive derivative of mycophenolic acid with 4-(2-hydroxyethyl)morpholine under acidic reaction conditions and the subsequent extraction of the pure mycophenolate mofetil through salt formation and release of the free base. A further aspect of the invention relates to the purification of mycophenolate mofetil by removing its by-products, in particular its dimeric by-products, by means of treatment with a primary or secondary amine.
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申请公布号 |
US2007032483(A1) |
申请公布日期 |
2007.02.08 |
申请号 |
US20060570641 |
申请日期 |
2006.09.29 |
申请人 |
GREIL JULIA;LUDESCHER JOHANNES;WOLF SIEGFRIED |
发明人 |
GREIL JULIA;LUDESCHER JOHANNES;WOLF SIEGFRIED |
分类号 |
A61K31/5377;C07D307/88;C07D413/02 |
主分类号 |
A61K31/5377 |
代理机构 |
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主权项 |
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地址 |
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