The present invention is directed to methods to determine the likelihood of therapeutic effectiveness of a farnesyl transferase inhibitor (FTI). The method comprises determining whether the gene encoding the farnesyl transferase beta subunit (FNTB) of said patient comprises at least one nucleic acid variance that causes an alteration in an amino acid residue. The change in the amino acid residue is associated with resistance to a FTI. The absence of at least one variance indicates that the FTI is likely to be effective.
申请公布号
WO2006128180(A9)
申请公布日期
2007.02.08
申请号
WO2006US20933
申请日期
2006.05.30
申请人
CHILDREN'S MEDICAL CENTER CORPORATION;DALEY, GEORGE, Q.;RAZ, TAL;AZAM, MOHAMMAD