METHOD OF OBTAINING PHENYL CARBAMATES

摘要

The invention relates to a method of obtaining phenyl carbamates (I), wherein R₁ is lower alkyl C₁-C₅ or benzyl and R₂ is methyl, ethyl or propyl, consisting in reacting L-(S)-3-[(1-methylamino)ethyl]phenol, in the presence of a base, with a carbamoyl halide in order to obtain an intermediate and, subsequently, subjecting said intermediate to a reducing amination reaction or a methylation reaction by reacting same with a methyl halide. The above-mentioned compounds (I) include rivastigmine, a compound that inhibits cholinesterase in the central nervous system, and can be used in the treatment of neurodegenerative diseases (e.g. senile dementia and Alzheimer's disease).