发明名称 |
REAGENTS FOR THE DETECTION OF PHOSPHORYLATED ATR KINASE (SER 428/SER 2317) AND USES THEREOF |
摘要 |
The invention discloses two novel phosphorylation sites in human ATR kinase, serine 428 (Ser428) and serine 2317 (Ser2317) respectively, and provides reagents, including antibodies and AQUA peptides, that selectively bind to and/or detect ATR only when phosphorylated at one or more of these respective sites, but do not bind to ATR when not phosphorylated at these respective sites. Also provided are methods for determining the phosphorylation of ATR kinase in a biological sample, by using a detectable reagent that binds to ATR only when phosphorylated at Ser428 and/or Ser2317. Kits comprising the ATR (Ser428, Ser2317)- specific reagents of the invention are also provided. |
申请公布号 |
WO2007015840(A2) |
申请公布日期 |
2007.02.08 |
申请号 |
WO2006US27791 |
申请日期 |
2006.07.18 |
申请人 |
CELL SIGNALING TECHNOLOGY, INC.;LIVINGSTONE, MARK;RUAN, HONG;POLAKIEWICZ, ROBERTO |
发明人 |
LIVINGSTONE, MARK;RUAN, HONG;POLAKIEWICZ, ROBERTO |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|