Methods and compositions concerning mutant flaviviruses with reduced virulence. In some embodiments the invention concerns nucleotide sequences that encode mutant flaviviral proteins. Viruses comprising mutant NSl and NS4B genes display reduced virulence are provided. In further aspects of the invention, flavivirus vaccine compositions such as West Nile virus vaccines are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.
申请公布号
WO2007015783(A2)
申请公布日期
2007.02.08
申请号
WO2006US27565
申请日期
2006.07.14
申请人
RESEARCH DEVELOPMENT FOUNDATION;WICKER, JASON, A.;WHITEMAN, MELISSA, C.;BARRETT, ALAN, D. T.
发明人
WICKER, JASON, A.;WHITEMAN, MELISSA, C.;BARRETT, ALAN, D. T.