发明名称 |
MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE |
摘要 |
<p num="1"><br/><br/><br/>Disclosed herein are sulfonamide compounds of Formula (VII) as described <br/>herein. Methods and compositions are disclosed for treating disease states <br/>including, but not limited to cancers, autoimmune diseases, tissue damage, <br/>central nervous system disorders, neurodegenerative disorders, fibrosis, bone <br/>disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory <br/>conditions, cardiovascular conditions, and disorders in which angiogenesis <br/>play a role in pathogenesis, using the compounds of the invention. In <br/>addition, methods of modulating the activity of histone deacetylase (HDAC) are <br/>also disclosed.<br/>
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申请公布号 |
CA2615574(A1) |
申请公布日期 |
2007.02.08 |
申请号 |
CA20062615574 |
申请日期 |
2006.07.27 |
申请人 |
KALYPSYS, INC. |
发明人 |
SCRANTON, SHAWN A.;PAYNE, JOSEPH E.;MALECHA, JAMES W.;HOFFMAN, TIMOTHY Z.;NOBLE, STEWART A.;BONNEFOUS, CELINE;SMITH, NICHOLAS D.;HASSIG, CHRISTIAN A.;WASH, PAUL L.;WILEY, BRANDON M.;SERTIC, MICHAEL;HAGER, JEFFREY H. |
分类号 |
C07D405/12;A61K31/4427;A61P9/00;A61P25/00;A61P29/00;A61P35/00;C07D401/12;C07D401/14;C07D405/14;C07D413/12;C07D417/12 |
主分类号 |
C07D405/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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