METHOD FOR PRODUCING OPTICALLY ACTIVE HYDROXYAMINO ACID DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To provide a new method for easily producing an optically active 3-hydroxyamino acid derivative in higher optical purity at a low cost. SOLUTION: The method for producing an optically active 3-hydroxyamino acid derivative comprises the formation of a 3-oxoamino acid derivative of formula (2) (R1is an alkyl, an aryl or a heterocyclic group; R2is a≥4C alkyl, a≥4C alkoxy, an aryl or a heterocyclic group; R3is an alkyl or an aryl; the alkyl, alkoxy, aryl or heterocyclic group in R1to R3may have substituents) with a microbial cell and/or treated cell of a microorganism capable of stereospecifically reducing theβ-carbonyl group of the 3-oxoamino acid derivative. COPYRIGHT: (C)2007,JPO&INPIT