发明名称 |
A SOLID PHARMACEUTICAL COMPOSITION WITH A FIRST FRACTION OF A DISPERSION MEDIUM AND A SECOND FRACTION OF A MATRIX, THE LATTER BEING AT LEAST PARTIALLY FIRST EXPOSED TO GASTROINTESTINAL FLUIDS |
摘要 |
A solid pharmaceutical composition in the form of a single dosage unit for oral use, the composition comprising a first and a second fraction, the first fraction comprises a therapeutically and/or prophylactically active substance dispersed in a dispersion medium that is sufficiently fluid at body temperature and the second fraction comprises a matrix comprising a substantially water soluble and/or crystalline polymer or a mixture of substantially water soluble and/or crystalline polymers, the first fraction being included in the composition in such a manner that at least a part of the second fraction is firstly exposed to the gastrointestinal fluids upon administration before the first fraction becomes exposed. The system is designed to release the active substance after a predetermined period of time after administration, and the release of the active substance at that point in time is relatively fast. |
申请公布号 |
WO2006128471(A3) |
申请公布日期 |
2007.02.08 |
申请号 |
WO2006DK00312 |
申请日期 |
2006.06.02 |
申请人 |
EGALET A/S;BAR-SHALOM, DANIEL;SLOT, LILLIAN |
发明人 |
BAR-SHALOM, DANIEL;SLOT, LILLIAN |
分类号 |
A61K9/28;A61K31/57;A61K38/23 |
主分类号 |
A61K9/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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