发明名称 |
CD33-specific single-chain immunotoxin and method of use |
摘要 |
<p>A single-chain immunotoxin composition and method of treatment with the composition is disclosed. Preferably, the immunotoxin is comprised of a CD33-specific single chain Fv antibody fragment and a genetically engineered variant of Pseudomonas Exotoxin A (ETA). A preferred engineered Exotoxin A is referred to ETA' and may includes a KDEL peptide at its C-terminus, a cellular peptide mediating improved retrograde transport to the endoplasmic reticulum (ER). The immunotoxin compound may be formulated with a carrier and administered into patients where the antibody portion binds to CD33-positive cells and kills those cells to provide an effective treatment for diseases such as human myeloid leukemia.</p> |
申请公布号 |
AU2006275038(A1) |
申请公布日期 |
2007.02.08 |
申请号 |
AU20060275038 |
申请日期 |
2006.07.31 |
申请人 |
FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NURNBERG |
发明人 |
GEORG H. FEY;MICHAEL SCHWEMMLEIN |
分类号 |
C07K19/00;A61K39/395;A61P35/02;C07K14/21;C07K16/28 |
主分类号 |
C07K19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|