发明名称 Novel aryloxyphenyl-propanamines
摘要 The present invention relates to a non-radioactive, heavy-atom isotopologue of Compound 1 containing one or more deuterium in place of a hydrogen covalently bound to carbon. The Compound 1 isotopologues of the invention are inhibitors of norepinephrine uptake and possess unique biopharmaceutical and pharmacokinetic properties compared to the corresponding non-isotope containing compounds. They may also be used to accurately determine the concentration of Compound 1 in biological fluids. The invention further provides compositions comprising these heavy-atom Compound 1 isotopologue and methods of treating diseases and conditions linked to reduced neurotransmission of norepinephrine.
申请公布号 US2007032555(A1) 申请公布日期 2007.02.08
申请号 US20060480265 申请日期 2006.06.30
申请人 CONCERT PHARMACEUTICALS INC. 发明人 TUNG ROGER
分类号 A61K31/138;C07C217/16 主分类号 A61K31/138
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