REGULATION OF TISSUE FACTOR ACTIVITY BY PROTEIN S AND TISSUE FACTOR PATHWAY INHIBITOR
摘要
The present invention relates to methods for the identification of compounds that increase or decrease the inhibitory effect of TFPI on tissue factor activity and/or Factor Xa activity and/or thrombin formation. The invention also relates to methods for the identification of compounds that increase or decrease the co-factor activity of Protein S in TFPI-mediated inhibition of tissue factor and/or Factor Xa activity. The invention also relates to a pharmaceutical composition comprising the compounds identifiable by such methods. The invention also relates to methods for the regulation of tissue factor activity by influencing the interaction between Protein S and Tissue Factor Pathway Inhibitor.
申请公布号
WO2007014749(A2)
申请公布日期
2007.02.08
申请号
WO2006EP07597
申请日期
2006.07.28
申请人
UNIVERSITEIT VAN MAASTRICHT;HACKENG, TILMAN, M.;SERE, KRISTIN, M.;TANS, GUIDO;ROSING, JAN
发明人
HACKENG, TILMAN, M.;SERE, KRISTIN, M.;TANS, GUIDO;ROSING, JAN