发明名称 |
Screening molecules with anti-prion activity: kits, methods and screened molecules |
摘要 |
A kit and a method for identifying compounds having anti-prion activity are provided. The kit comprises a yeast of phenotype [PSI+]; an antibiogram; and a prion curing agent in a sub-effective dose, wherein the yeast has the adel-14 allele of the ADE1 gene and an inactivated ERG6 gene. Compounds and pharmaceutical compositions having anti-prion activity are also provided, which are useful for treating various neurodegenerative diseases, including polyglutamines expansion associated diseases; Huntington's disease; Kennedy disease; amyotrophic lateral sclerosis; cerebellous autosomic ataxies; dentalorubral-pallidoluysian atrophy; and spino-bulbar amyotrophy.
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申请公布号 |
US2007031821(A1) |
申请公布日期 |
2007.02.08 |
申请号 |
US20060483822 |
申请日期 |
2006.07.11 |
申请人 |
UNIVERSITE DE POITIERS |
发明人 |
BLONDEL MARC;CULLIN CHRISTOPHE;VIERFOND JEAN M.;BERTOLOTTI ANNE;BACH STEPHANE;TALAREK NICOLAS;METTEY YVETTE |
分类号 |
C12Q1/00;A61K31/473;A61K31/554;A61P25/28;C12N1/19;C12Q1/02 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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