| 摘要 |
The invention relates to an anhydrous multiphase gel system consisting of an outer lipid matrix and of an inner phase gelled by means of polymer, obtaine d by: a) melting the lipid phase while forming a liquid lipid phase; b) mixing and homogenizing polymers or polymer blends that are capable of swelling whi le forming a polymer phase to be dispersed; combining the polymer phase with th e liquid lipid phase and homogenizing the phases, and; d) cold stirring the phase mixture until forming a solid gel-like mixed structure of the entire system. The anhydrous multiphase gel system is particularly suited for accommodating poorly soluble active substances in high concentrations and fo r topical and transdermal applications. The described system is characterized as an EDRS Entrapped Drug Reservoir System . |
