| 摘要 |
High expression locus vectors based, in part, on the ferritin heavy chain locus are disclosed. The vectors include distal 5' flanking sequences and/or proximal 5' regulatory sequences derived from ferritin heavy chain locus. The vectors include a site for insertion of heterologous sequences and proximal 3' regulatory and distal 3+ flanking sequences. The proximal 3' regulatory and distal 3' flanking sequences are optionally derived from the ferritin heavy chain locus. Cells transformed with the vectors, and methods of producing heterologous proteins encoded by the vectors, are also disclosed.
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