发明名称 |
Vaccine |
摘要 |
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection. |
申请公布号 |
US2007031449(A1) |
申请公布日期 |
2007.02.08 |
申请号 |
US20060584362 |
申请日期 |
2006.06.23 |
申请人 |
BOS MARTINE P;POOLMAN JAN;TEFSEN BORIS;TOMMASSEN JOHANNES P M |
发明人 |
BOS MARTINE P.;POOLMAN JAN;TEFSEN BORIS;TOMMASSEN JOHANNES P.M. |
分类号 |
A61K39/116;A61K35/74;C07K14/22;C07K14/315;C07K16/12 |
主分类号 |
A61K39/116 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|