PROTECTION OF TRANSPLANTED STEM CELLS WITH HMG-COA REDUCTASE INHIBITORS

摘要

Impaired remyeliiiation due to degeneration of both postmitotic oligodendrocytes and oligodendrocyte progenitors (OPs) is the major hallmark of inflammatory demyelination in multiple sclerosis (MS) lesions and other inflammatory diseases. HMG-CoA reductase inhibitors also are proposed to stimulate and protect stems cells, such as OPs, for example in the context of transplantation.