TABLETS WITH IMPROVED DRUG SUBSTANCE DISPERSIBILITY

摘要

The present invention relates to a method for the preparation of pharmaceutical compositions in the form of tablets with improved drug substance dispersibility, said method being characterized in that it comprises the steps of: a) preparing a dispersion of at least one pharmaceutically active drug substance and at least one surfactant and/or binder in a liquid; b) preparing a carrier by dry blending one or more excipient(s) including at least one porous carrier; and c) spray granulating the dispersion prepared under a) onto the carrier prepared under b) in order to obtain a spray-granulated product.