<p>The present invention concerns a labelling reagent in which the label is bound via an amide bond and a linker to a residue of the molecule which is essentially characterized in that the N atom of the amide bond and the label are linked together directly by a covalent bond. In particular these are phosphoramidites or reactive supports suitable for nucleic acid synthesis. The invention also concerns processes for the production of such supports from suitable precursors.</p>
申请公布号
EP1186613(B8)
申请公布日期
2007.02.07
申请号
EP20010121139
申请日期
2001.09.04
申请人
ROCHE DIAGNOSTICS GMBH;F. HOFFMANN-LA ROCHE AG
发明人
HEINDL, DIETER, DR.;SAGNER, GREGOR, DR.;MAERZ, HERIBERT;VON DER ELTZ, HERBERT, DR.