| 发明名称 |
Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
| 摘要 |
Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility in a therapeutically effective amount, wherein the drug is present in the form of solid particle, about 25% to 100% by weight of which are smaller than 1 mum. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders and have particular advantages where rapid onset of therapeutic effect is desired.
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| 申请公布号 |
US7172769(B2) |
申请公布日期 |
2007.02.06 |
| 申请号 |
US20020031898 |
申请日期 |
2002.07.30 |
| 申请人 |
PHARMACIA CORPORATION |
发明人 |
KARARLI TUGRUL T.;KONTNY MARK J.;DESAI SUBHASH;HAGEMAN MICHAEL J.;HASKELL ROYAL J. |
| 分类号 |
A61K9/50;C07D233/60;A61K9/14;A61K9/20;A61K9/24;A61K9/26;A61K9/48;A61K31/34;A61K31/341;A61K31/352;A61K31/41;A61K31/415;A61K31/42;A61K31/44;A61K31/444;A61K45/00;A61K45/06;A61P1/00;A61P1/02;A61P1/04;A61P1/16;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P15/00;A61P15/04;A61P17/00;A61P17/02;A61P17/06;A61P17/10;A61P19/02;A61P19/10;A61P21/00;A61P21/04;A61P25/00;A61P25/06;A61P25/28;A61P25/32;A61P27/02;A61P27/12;A61P29/00;A61P31/12;A61P31/18;A61P35/00;A61P37/08;A61P43/00;C07D213/61;C07D231/12;C07D261/08;C07D307/58;C07D311/58 |
主分类号 |
A61K9/50 |
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