发明名称 |
FBL2-specific agents as modulators of Flaviviridae RNA replication |
摘要 |
Agents that modulate an interaction of an FBL2 protein with an NS5A or NS5B Flaviviridae protein in a mixture are identified by contacting the mixture with a candidate agent under conditions wherein but for the presence of the agent, the FBL2 protein and the Flaviviridae protein engage in a reference interaction; and detecting an agent-biased interaction. Flaviviridae replication is inhibited by contacting a Flaviviridae-infected cell with an FBL2-specific reagent; and detecting a resultant Flaviviridae replication inhibition.
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申请公布号 |
US7172862(B2) |
申请公布日期 |
2007.02.06 |
申请号 |
US20050122373 |
申请日期 |
2005.05.04 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GALE, JR. MICHAEL J.;BROWN MICHAEL S.;GOLDSTEIN JOSEPH L.;WANG CHUNFU;YE JIN |
分类号 |
C12Q1/70;C12P21/06;G01N33/53 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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