| 发明名称 |
REGIOSPECIFIC SYNTHESIS OF RAPAMYCIN 42-ESTER DERIVATIVES |
| 摘要 |
A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acylation of 42 hydroxy rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent. ® KIPO & WIPO 2007
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| 申请公布号 |
KR20070015544(A) |
申请公布日期 |
2007.02.05 |
| 申请号 |
KR20067021378 |
申请日期 |
2006.10.13 |
| 申请人 |
WYETH |
发明人 |
GU JIANXIN;CAI PING;RUPPEN MARK E. |
| 分类号 |
C07D498/18;A61K31/436;C07D491/14;C12N9/20;C12P17/10;C12P17/18 |
主分类号 |
C07D498/18 |
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