PROCESS OF PRODUCING BEPROMOLINE

摘要

The present invention refers to a process of manufacturing a compound of formula (Ia), said process comprising: (i) contacting a compound of formula (III) with a compound of formula (IV) in the presence of a palladium catalyst, methanol and hydrogen gas, said step (i) being conducted preferably under basic conditions with acetic acid added once the consumption of the hydrogen gas has ceased.