AGONISTEN DES PEROXISOM AKTIVATOR-RESPONSIVEN REZEPTORS

摘要

A method of promoting binding of a peroxisome proliferator-activated receptor to a target gene sequence and promoting gene expression downstream thereof in a human or animal comprises administering to the human or animal a preventively or therapeutically effective dose of a peroxisome proliferator-activated receptor agonist comprising at least one selected from conjugated unsaturated fatty acids having 10 to 26 carbon atoms and containing a conjugated trienoic structure (-CH=CH-CH=CH-CH=CH-) or a conjugated tetraenoic structure (-CH=CH-CH=CH-CH=CH-CH=CH-) in the molecule thereof, and salts and ester derivatives thereof. Using this method, reduction of visceral fat amount or suppression of visceral fat accumulation, prevention or amelioration of lipid metabolism abnormalities, prevention or amelioration of glucose metabolism abnormalities, or prevention or treatment of cancer can be carried out in the human or animal.