发明名称 |
METHOD OF PREPARING ESOMEPRAZOLE AND SALTS THEREOF |
摘要 |
Optically pure esomeprazole and its salt can be simply prepared by dissolving (S)-(-)-binol, a weak base and the racemic form of omeprazole in a mixture of a water-compatible organic solvent and water at a high temperature, cooling the mixed solution to crystallize the inclusion complex of esomeprazole and (S)-(-)-binol, and removing the (S)-(-)-binol moiety from the crystallized inclusion complex.
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申请公布号 |
CA2616119(A1) |
申请公布日期 |
2007.02.01 |
申请号 |
CA20062616119 |
申请日期 |
2006.07.11 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
KIM, WON JEONG;OH, HEE SOOK;PARK, CHANG HEE;HA, TAE HEE;LEE, JAE CHUL;KIM, HAN KYONG;SUH, KWEE-HYUN |
分类号 |
C07D401/12;A61P1/04 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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