| 摘要 |
The present invention provides the use of a compound of the Formula: (I) wherein R<SUP>1</SUP> is C<SUB>1-5</SUB> alkoxy, OCOC<SUB>1-3</SUB>Alkyl, O(CH<SUB>2</SUB>)<SUB>2</SUB>O(CH<SUB>2</SUB>)<SUB>2</SUB>O(CH<SUB>2</SUB>)<SUB>2</SUB>OMe, O(CH<SUB>2</SUB>)<SUB>2</SUB>O(CH<SUB>2</SUB>)<SUB>2</SUB>O(CH<SUB>2</SUB>)<SUB>2</SUB>OH or OH; R<SUP>2</SUP> is H, (CH<SUB>2</SUB>)<SUB>n</SUB>OH, OCH<SUB>3</SUB>, Hal or (II) or (III) R<SUP>3</SUP> is H or (CH<SUB>2</SUB>)<SUB>n</SUB>OH; and R<SUP>4</SUP> is C<SUB>1-6</SUB> alkyl, optionally substituted by one or more of Hal, OH, COCH<SUB>3</SUB>, NH<SUB>2</SUB>, NHCH<SUB>3</SUB>, NHMe, NMe<SUB>2</SUB>, OCOCH<SUB>3</SUB>, CO<SUB>2</SUB>H or esters or amides thereof where n is 1-5; and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in modulating PKB activity. |
| 申请人 |
IMPERIAL INNOVATIONS LIMITED;WOSCHOLSKI, RUDIGER;HAILES, HELEN;NUMBERE, MACBA;ROSIVATZ, ERIKA |
发明人 |
WOSCHOLSKI, RUDIGER;HAILES, HELEN;NUMBERE, MACBA;ROSIVATZ, ERIKA |
