Novel use of cannabinoid receptor agonist

摘要

An inhibitor for an inflammatory cell infiltration in the respiratory tract, an inhibitor for hyperirritability in the respiratory tract, a muciparous inhibitor, or a bronchodilator which contains as an active ingredient a compound represented by the formula (I) or (II): wherein R¹ is the group represented by the formula: -C(=Z)-W-R⁴ wherein Z is an oxygen atom or the like; W is an oxygen atom or the like; R⁴ is optionally substituted alkyl or the like; R² and R³ are independently optionally substituted alkyl or the like; or R² and R³ are taken together to form optionally substituted alkylene which may contain a heteroatom(s); m is an integer of 0 to 2; A is optionally substituted aryl or optionally substituted heteroaryl; wherein R⁵ is the group represented by the formula: -Y¹-Y²-Y³-R^a wherein Y¹ and Y³ are each independently a bond or the like; Y² is -C(-O)-NR^b- or the like; R^a is optionally substituted alkyl, or the like; R^b is a hydrogen atom or the like; R⁶ is a hydrogen atom or the like; R⁷ and R⁸ are each independently optionally substituted alkyl or the like; or R⁷ and R⁸ are taken together with the adjacent carbon atoms to form a 5 to 8 membered ring which may contain a heteroatom(s) and/or an unsaturated bond(s); R⁹ is optionally substituted alkyl which may contain a heteroatom(s) and/or an unsaturated bond(s), or the like; X is a oxygen atom or the like.