发明名称 |
HDAC REGULATION ASSAYS, COMPOUNDS AND THERAPEUTIC COMPOSITIONS |
摘要 |
This invention relates to the field of assays for compounds that interact with the binding of a PTB-containing protein, i.e. APPL (Adaptor protein containing PH domain, PTB domain and Leucine zipper motif) with histone deacetylase, in particular HDACl. Compounds identified using said assays are useful in inhibiting HDAC activity and as a medicine, in particular in the manufacture of a medicament to inhibit proliferative conditions, such as cancer and psoriasis. |
申请公布号 |
WO2006131496(A3) |
申请公布日期 |
2007.02.01 |
申请号 |
WO2006EP62859 |
申请日期 |
2006.06.02 |
申请人 |
JANSSEN PHARMACEUTICA N.V.;DE SCHEPPER, STEFANIE HELENA;ARTS, JANINE;VIALARD, JORGE EDUARDO;ANDRIES, LUC JOSEPH |
发明人 |
DE SCHEPPER, STEFANIE HELENA;ARTS, JANINE;VIALARD, JORGE EDUARDO;ANDRIES, LUC JOSEPH |
分类号 |
C12Q1/44;A61P17/06;A61P35/00;C12N9/16 |
主分类号 |
C12Q1/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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