| 摘要 |
The present invention concerns oral dosage formulations of sparingly to very slightly water soluble proton pump inhibitors, the oral dosage forms so made, and methods of use thereof. The oral dosage form has a core tablet of compressed particles composed of powder particles of a pharmaceutically acceptable material, having coated thereon admixture of a sparingly to very slightly water soluble magnesium salt of a benzimidazole proton pump inhibitor; and a hydrophilic polymer having a surfactant functionality that increases the water solubility of the magnesium salt of the benzimidazole proton pump inhibitor. The coated core tablet has a pharmaceutically acceptable sub-coating on the core tablet; and a pharmaceutically acceptable enteric coating on the sub-coating. The coated tablet may provide enhanced absorption when administered orally.
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