发明名称 |
PROCESS FOR PRODUCTION OF MONO-SUBSTITUTED ALKYLATED COMPOUND USING ALDIMINE OR DERIVATIVE THEREOF |
摘要 |
<p>Disclosed is a process for producing an asymmetric mono-substituted alkylated compound of an a-amino acid which is represented by a specific formula by using an aldimine-type Schiff base. In the process, the alkylation of an aldimine-type Schiff base in a medium in the presence of an optically active quaternary ammonium salt phase transfer catalyst and an inorganic base is started, and subsequently the reaction is quenched at any time preceding the completion of the stoichimetrical reaction, thereby yielding a mono-substituted alkylated product having a high optical purity.</p> |
申请公布号 |
WO2007013698(A1) |
申请公布日期 |
2007.02.01 |
申请号 |
WO2006JP315457 |
申请日期 |
2006.07.28 |
申请人 |
NAGASE & CO., LTD.;MARUOKA, KEIJI;INOUE, TORU;MATSUMOTO, JUN |
发明人 |
MARUOKA, KEIJI;INOUE, TORU;MATSUMOTO, JUN |
分类号 |
C07C249/02;B01J31/02;C07B53/00;C07B61/00;C07C227/04;C07C229/36;C07C251/24 |
主分类号 |
C07C249/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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