Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
申请公布号
CA2617063(A1)
申请公布日期
2007.02.01
申请号
CA20062617063
申请日期
2006.07.26
申请人
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;MERCK & CO., INC.
发明人
KELLY, ROSEMARIE;KAHN, JENNIFER NIELSEN;DOUGLAS, CAMERON M.;PARK, STEVEN;PARENT, STEPHEN A.;PERLIN, DAVID S.