发明名称 |
PH-CONTROLLED PULSATILE DELIVERY SYSTEM, METHODS FOR PREPARATION AND USE THEREOF |
摘要 |
The invention relates to delivery systems that allow for the pulsatile release of a substance, such as a drug, in response to a change in pH. More specifically, it relates to drug administration to the GI tract, in particular to site-specific intestinal drug delivery via the oral route. Provided is a pH-controlled pulsatile release system (PPRS) comprising a core surrounded by a coating layer, wherein said core comprises an active substance and wherein said coating layer comprises a pH-sensitive coating material wherein a swellable agent is embedded. Said swellable agent is capable of taking up at least 1.1 times, preferably at least 5 times, more preferably at least 10 times its weight in water. Also provided is a pharmaceutical composition comprising a PPRS, in particular a colon-specific PPRS. |
申请公布号 |
WO2007013794(A1) |
申请公布日期 |
2007.02.01 |
申请号 |
WO2005NL00559 |
申请日期 |
2005.07.29 |
申请人 |
STICHTING GRONINGEN CENTRE FOR DRUG RESEARCH;SCHELLEKENS, REINOUT CORNELUS ANDREAS;FRIJLINK, HENDERIK WILLEM |
发明人 |
SCHELLEKENS, REINOUT CORNELUS ANDREAS;FRIJLINK, HENDERIK WILLEM |
分类号 |
A61K9/00;A61K9/20;A61K9/28;A61K9/50;A61K31/00;A61K39/00;A61K47/30 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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