| 发明名称 |
Chloral-free DCA in oligonucleotide synthesis |
| 摘要 |
A process of manufacturing oligonucleotides includes a 5'-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
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| 申请公布号 |
US7169916(B2) |
申请公布日期 |
2007.01.30 |
| 申请号 |
US20030403692 |
申请日期 |
2003.03.31 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
KROTZ ACHIM;CAPALDI DANIEL;GAUS HANS;TURNEY BRETT |
| 分类号 |
C07H21/00 |
主分类号 |
C07H21/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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