发明名称 |
Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors |
摘要 |
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.
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申请公布号 |
US7169809(B2) |
申请公布日期 |
2007.01.30 |
申请号 |
US20040790288 |
申请日期 |
2004.03.01 |
申请人 |
MERCK FROSST COMPANY |
发明人 |
BERTHELETTE CARL;LI LIANHAI;STURINO CLAUDIO;WANG ZHAOYIN |
分类号 |
A61K31/21;A61P29/00;C07C317/46 |
主分类号 |
A61K31/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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