Quinoline derivatives and quinazoline derivatives

摘要

An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R¹ to R³ represent H, substituted alkoxy, unsubstituted alkoxy or the like; R⁴ represents H; R⁵ to R⁸ represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R⁵ to R⁸ do not simultaneously represent H; R⁹ and R¹⁰ represent H, alkyl, or alkylcarbonyl; and R¹¹ represents alkyl, alkenyl, alkynyl, or aralkyl.