发明名称 |
Analogs of epothilone |
摘要 |
Designed epoxide and cyclopropane epothilone analogs with substituted side-chains are disclosed and characterized with respect to their biological activities against a series of human cancer cell lines. Among the several bioactive analogs, the epothilone B analog with a thiomethyl thiazole ring stands out as the most potent.
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申请公布号 |
US7169930(B2) |
申请公布日期 |
2007.01.30 |
申请号 |
US20030634537 |
申请日期 |
2003.08.04 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
NICOLAOU KYRIACOS C.;RITZEN ANDREAS;NAMOTO KENJI |
分类号 |
C07D417/06;A61K31/427;A61K31/4427;A61K31/4433;A61P17/06;A61P35/00;C07D405/06;C07D407/06;C07D417/02;C07D493/04 |
主分类号 |
C07D417/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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