Compositions and methods for priming monocytic dendritic cells and T cells for TH-1 response using BCG and IFN gamma

摘要

A method for producing a mature dendritic cell population comprising: (a) providing immature dendritic cells; and (b) contacting the immature dendritic cells with an effective amount of BCG and Interferon gamma under culture conditions suitable for the maturation of the immature dendritic cell population to form a mature dendritic cell population; wherein the mature dendritic cell population produces an increased ratio of Interleukin 12 to Interleukin 10 than an immature dendritic cell population not contacted with BCG and Interferon gamma during maturation. Also described are compositions for activating T cells; methods for producing T cells; isolated, mature dendritic cells producing more Interleukin 12 to Interleukin 10; methods for producing a type 1 immune response.