Method for manufacture of sertindole

摘要

Disclosed is a method for manufacture of sertindole comprising manufacturing 5-chloro-1--(4-fluorophenyl)-indole and converting it to sertindole characterised in that the method for manufacture of 5-chloro-1-(4-fluorophenyl)-indole comprises reacting 5-chloro-indole with a 4-fluorophenylhalide in the presence of a base, a chelating ligand and catalytic amounts of a copper salt comprising copper(l) or copper(ll) and an anion which does not interfere in an unfavourable way with the reaction.