发明名称 |
The use of anti-histaminics for acute reduction of elevated intracranial pressure |
摘要 |
Histamine receptor antagonists and the use of an histamine receptor antagonist for the reduction of intracranial pressure (ICP), in particular for the prevention and treatment of elevated intracranial pressure and/or secondary ischaemia, in particular caused by brain injury, more in particular caused by traumatic (TBI) and non-traumatic brain injury. The compounds comprise compounds according to the general Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof. In particular, the preferred compound is 3-[2-[4-(11,12-dihydro-6H-benzimidazo[2,1-b][3]benzazepin-6-yl)-2-(phenylmethyl)-1-piperidinyl]ethyl]-2,10-dimethyl pyrimido[1,2-a]benzimidazol-4(10H)-one, the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof. Also disclosed is the use of commercially available histamine H1-and H2-receptor antagonists for the reduction of intracranial pressure (ICP).
|
申请公布号 |
NZ532718(A) |
申请公布日期 |
2007.01.26 |
申请号 |
NZ20020532718 |
申请日期 |
2002.11.22 |
申请人 |
JANSSEN PHARMACEUTICA N |
发明人 |
TEGTMEIER, FRANK;JANSSENS, FRANS EDUARD;LEENAERTS, JOSEPH ELISABETH;VAN ROSSEM, KOENRAAD ARTHUR;ALCAZAR-VACA, MANUEL JESUS;MARTINEZ-JIMENEZ, PEDRO;BARTOLOME-NEBREDA, JOSE MANUEL;GOMEZ-SANCHEZ, ANTONIO;FERNANDEZ-GADEA, FRANCISCO JAVIER;VAN REEMPTS, JOZEF LEO HENRI |
分类号 |
C07D487/04;A61K31/415;A61K31/425;A61K31/513;A61K31/517;A61K31/519;A61K31/55;A61P1/04;A61P9/10;A61P29/00;A61P37/02;A61P37/06;A61P37/08;C07D471/00;C07D471/04;C07D487/00;C07D519/00;(IPC1-7):C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|