PYRAZOLE DERIVATIVES AS CBl MODULATORS

摘要

The present invention relates to compounds of formula (I) wherein R<SUP>1</SUP> represents a group R<SUP>5</SUP>O- in which R<SUP>5</SUP> represents a C<SUB>3-7</SUB>alkyl group substituted by one or more fluoro or R<SUP>5</SUP> represents a C<SUB>3-7</SUB>alkylsulphonyl group which is optionally substituted by one or more fluoro; R<SUP>2</SUP> represents a C<SUB>1-4</SUB>alkyl group, hydroxy, fluoro, chloro or cyano wherein each R<SUP>2</SUP> is independently selected when n is >1; R<SUP>3</SUP> represents a) cyclohexyl optionally substituted by one or more of the following: hydroxy, fluoro, amino, mono or diC<SUB>1-3</SUB>alkylamino, carboxy or a C<SUB>1-4</SUB>alkoxycarbonyl group b) piperidino substituted by one or more hydroxy c) unsubstituted piperidino but only when one of the following applies: R<SUP>4</SUP> represents cyano or R<SUP>1</SUP> represents 3-fluoropropylsulphonyloxy or R<SUP>1</SUP> represents 3,3,3-trifluoropropoxy or R<SUP>1</SUP> represents 3-fluoropropoxy or R<SUP>2</SUP> is methyl d) phenyl substituted by one or more of the following: hydroxy, halo or a C<SUB>1-4</SUB>alkyl group e) pyridyl substituted by a C<SUB>1-4</SUB>alkyl group or f) a C<SUB>4-9</SUB>alkyl group; R<SUP>4</SUP> represents cyano or methyl; and n is 1, 2 or 3 and pharmaceutically acceptable salts thereof and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.