SOLID DOSAGE FORMULATIONS OF NARCOTIC DRUGS HAVING IMPROVED BUCCAL ADSORPTION

摘要

Disclosed is a pharmaceutical composition in the form of a tablet suitable for dissolution in the buccal cavity, said composition comprising i) an effective amount of a narcotic active ingredient, and ii) a pharmaceutically acceptable amine having a pK of about 8 or greater, wherein the molar ratio of amine:active ingredient is at least about 5:1.