| 摘要 |
Formula (I) compounds are described c(R1-Arg- Gly-Asp-R2) where the meanings of the various groups are as described here below, which are integrin inhibitors, and particularly inhibitors of integrins of the alphavbeta3 and alphav beta5 family, and therefore are useful as medicaments, particularly for the treatment of the diseases underlying abnormal angiogenesis, such as retinopathy, acute renal failure, osteoporosis and metastases. The compounds described herein, when suitably labelled, are also useful as diagnostic agents, especially for the detection of small tumor masses and arterial occlusion events, and as targeted drug vectors. ® KIPO & WIPO 2007 |
